BACLOFEN

Baclofen is a GabaB receptor agonist (fan of GabaB) that is inhiBitory at synapses in the spinal cord (at the Back).

Baclofen is a muscle relaxer and an antispastic agent.
Baclofen is used to treat muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness.

The most common side effects associated with baclophen include drowsiness, dizziness, nausea and leg weakness. The incidence of these side effects is reduced by starting with a low dose of baclophen that is gradually increased. However, approximately one tenth of sufferers cannot tolerate baclophen. A rare complication is a confusional state that appears shortly after baclophen is started, but this resolves quickly when therapy is stopped. Baclophen should not be discontinued abruptly after prolonged use because hallucinations or seizures may occur. If these withdrawal symptoms do occur, the previous dose of baclophen is usually re-instituted and then gradually reduced.